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Dr.
David Atlan
General Manager
PhenoSystems SA
Rue
Rauter 33-34
1070 Bruxelles
Belgium
http://www.phenosystems.com
T. : +32 2 732 5793 or +32 2 736 8359
Fax:
+32 2 734 7740
david@phenosystems.com
PhenoSystems
SA is a young start up company with headquarters in Bois de Villers,
Wallonia
, and central offices in
Brussels
. The three founders have
the appropriate combination of complementary expertise to develop innovative IT
solutions in the genetic / health area as well as to bring them to market. Dr.
MD Pascale Benlian is cardiologist and molecular geneticist working at Hospital
Saint Antoine in Paris, Dr. David Atlan is a physicist with IT and industrial
R&D management ex perience, and Derek de Villenfagne established as a
successful entrepreneur.
PhenoSystems
SA is looking forward to participate in PatiMon, improving health of the
European Citizen, developing the communication between different disciplines and
expertise in fields such as IT, biology, biochemistry, genetics and offering
innovative solutions addressing health problems. We could contribute
significantly in the area of computer aided diagnostics of genetic diseases as
well as knowledge about mutations causing diseases. Information collected in
this area has an impact on the evaluation of risk factors as well as the
treatment required by patients.
CVs
Dr.
MD Pascale Benlian
pascale.benlian@sat.ap-hop-paris.fr
MD-PhD,
specialized as a cardiologist and as a molecular geneticist. Assistant
Professor; Full time tenure at the Department of Biochemistry and Molecular
Biology, Saint Antoine Medical School,
Paris
.
Clinical
interest: Consultation
mainly focused on familial and complex lipid disorders. Clinical chemistry for
the investigation of lipid disorders.
Scientific
interest: Molecular
genetics of lipid disorders. Coordinator of a French Network for the molecular
diagnosis of familial lipid disorders. Improvement of methods to better detect,
manage and treat inherited lipid disorders.
Academic
achievements:
Publications on the molecular genetics of LPL or LCAT deficiency; FH, FDB;
modulator alleles of non-cardiovascular diseases (ARMD, PBC); basic studies on
the structure of candidate gene loci. Author of didactic books on the genetics
of lipid disorders (latest published by Kluwer Academic publishers,
Boston
, 2001). Editor of the “Med-Ped
Newsletter” (2001), suppl. to “Atherosclerosis” on inherited lipid
disorders. Member of the executive committee of the EAS, the ELC. Scientific
Award winner from the
French
Academy
of Medicine (2001). Member of the
Congress Program Committee of the European Society of Cardiology (2002).
Dr
David Atlan
Since
2002 : Development of Computer Aided Diagnostics Systems with PhenoSystems
SA in the field of genetics.
1995-2002 :
R&D and Product Supply management with Procter & Gamble in
Belgium
and
France
.
1995:
Doctor of Science, Université
de Lyon 1. Research on magnetic ultra thin films in ultra high vacuum at
Simon
Fraser
University
, Vancouver (Prof. B. Heinrich).
Bourse
Lavoisier du Ministère des Affaires Etrangères.
1991:
Magistère des Sciences de la Matière,
École Normale Supérieure
de Lyon. Licence, Maîtrise and DEA Sciences des Matériaux et des
Surfaces de Lyon : computational physics in the area of field emission.
Derek
de Villenfagne, BBA
Since
1999 : founder and General Manager of Crescential SA, specialised in the
development of global brands, such as SpanTech® shelter systems and custom
textile architecture, Immoglobe® Real Estate Management and consulting in the
area of technology start up projects.
2001 :
Prix du
jeune Entrepreneur de la Fondation Roi Baudouin for the SpanTech project
together with D. Atlan.
Publications
[Pheno1]
BENLIAN P., BONAITI C., DOUSTE-BLAZY P., JUNIEN C. Candidate gene approach to
type IIa hypercholesterolemia. The Lancet, (1989), vol. I, n° 8648, pp
1201-1202. (L)
[Pheno2]
BENLIAN P., BOILEAU C., LOUX N., PASTIER D., MASLIAH J., COULON M., NIGOU M.,
RAGAB A., GUIMARD J., RUIDAVETS J.B., BONAÏTI-PELLIÉ C., FRUCHART JC., DOUSTE
BLAZY P.,
BÉRÉZIAT
G., JUNIEN C. Extended haplotypes and linkage disequilibrium between 11 markers
at the ApoAI-CIII-AIV gene cluster on chromosome 11. American Journal of Human
Genetics,
(1991), vol 48, n°5, pp 903-910. (O)
[Pheno3]
BENLIAN P., Foubert L., GAGNÉ E., BERNARD L., de Gennes JL., LANGLOIS S.,
ROBINSON W., HAYDEN MR. Complete paternal isodisomy for chromosome 8 unmasked by
lipoprotein
lipase
deficiency. American Journal of Human Genetics (1996), n° 59, pp 431-436. (O)
[Pheno4]
BENLIAN P., de Gennes JL., Foubert L., ZHANG H., GAGNÉ E., HAYDEN MR. Premature
atherosclerosis in familial chylomicronemia caused by mutations in the
lipoprotein
lipase
gene. The New England Journal of Medicine (1996) , n°335, pp848-854. (O)
[Pheno5]
TEH EM., CHISHOLM JW., DOLPHIN PJ., POULIQUEN Y., SAVOLDELLI M., DE GENNES JL.,
BENLIAN P. Classical LCAT deficiency resulting from a novel homozygous
dinucleotide
deletion
in exon 4 of the human lecithin:cholesterol acyltransferase gene causing a
frameshift and stop codon at residue 144. Atherosclerosis (1999), n°146,
141-151. (O)
[Pheno6]
BENLIAN P. Genetics of Dyslipidemia. Collection Basic Science for the
Cardiologist. Editions KLUWER ACADEMIC PUBLISHERS , Boston MA, (2001), 320
pages.
[Pheno7]
Amsellem S., Briffaut D., Carrié A., Rabès J-P., Girardet J-P., Fredenrich A.,
Moulin P., Krempf M., Reznik Y., Vialettes B., De Gennes J- L, Brukert E.,
Benlian P.
[Pheno8]
Intronic mutations outside of Alu-repeat rich domains of the LDL receptor gene
are a cause of familial hypercholesterolemia. Human Genetics (2002), n°111 :
501-510. (O)
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