Cortical Information Processing in Mild Cognitive Impairment
AD is a
progressive, irreversible brain disorder with no known cause or cure. It attacks
and slowly steals the minds of its victims. Symptoms of the disease include
memory loss, confusion, impaired judgment, personality changes, disorientation,
and loss of language skills. Always fatal, AD is the most common form of
the most important presentation of the state of the art in the field of
Alzheimer disease is /33/. A consortium of high ranked experts around the world
present this knowledge:
“Importantly, heterogeneity in cognitive
impairments and cortical pathology of AD require multivariate models to
characterize it. Neuron, NFT, and SP densities do not fit a simple linear model
for the entire population and cannot be used as the sole analytical tool for
statistical analysis. … The more difficult issue, of course, is whether
statistical subgroups represent subtypes of the disease. … The etiology(ies)
of AD is/are not known.”/33, p. 126/7/.
“Furthermore, we need to gain a better understanding of how age-related differences in brain activation relate to differences in behavioral performance.” /33, p 222/.
“We speculate that AD may be caused by risk factors leading to sublethal vascular disease.” /33, p. 341/.
“Risk factors for the development of
Alzheimer’s disease (AD) include age, family history, low level of education,
head trauma, and gender. Epidemiological studies indicate that AD afflicts women
one-and-a-half to three times as frequently as men.“ /33, p. 469/.
growing number of studies and other research activities are carried out, however
this high ranked international publication demonstrates in impressive manner the
necessity to find a strategy for the solution of the named open problems.
important strategy is given by the design and application of Computer Aided
Solutions for different applications * - CA*S /3, ICS4/. Grid-technology is one
of the most important technical tool for the design of CA*S. The Open Grid
Services Architecture (OGSA) with the Globus Toolkit opened a new view for the
realisation of complex solutions: