B3 Potential impact  

The recognition and understanding of CIP and the destruction in MCI and AD requires the application of Computer Aided Systems in different applications CA*S for Intelligence Amplification. The project CIP-MCI proposes a strategy and realise the first steps in this direction in a very important and practical field of work. This strategy is designed as Holistic Approach.

O1: The first Objective is indirect proposed by E. Niedermeyer: “This work led us into a ‘brave new world’ of EEG computerisation and, as early as in 1967, we were told that customary EEG reading would soon be a thing of the past, replaced by a fully automatic EEG interpretation. ... It was found that EEG is by far too complex for such automation. Its interpretation requires that wonderful computer that is located between the ears.” /39 p. 12/. This “wonderful computer that is located between the ears” is able for signal recognition, understanding, reasoning and gather and distribute knowledge in excellent manner. However we all must accept, that the “customary EEG reading” is only possible by excellent technical support and the new quality is possible by the proposed by CA*S.

O2: The second Objective is indirect proposed by F.Crick: “The great advantage of the EEG is that its discrimination in time is rather good, in the range of a millisecond or so. Thus the rising and falling of the brain waves can be followed rather well. What is ness clear is what the waves signify.”/8, p. 111/.

The function and structure of the human brain is excellent, however nobody know the function of the cortex, the understanding and reasoning up to the decision and the generation of the reactions. The evaluation is only possible by the evaluation of the outcome, the behavior, and the language as body language and as most important: the natural language. The language is the universal and most important tool for knowledge transfer, teaching and learning. But we have an excellent and dynamic model named above by M. D. Lezak:

Computer systems e.g. CA*S for IA and as model for CIP!

We have designed and understand each detail of the structure and function in the digital world of the computer system.

If one wishes to recognise the function of the brain, one must use the most powerful tools: human intelligence, especially the natural language in communicative situations, supported by high performance computer systems, worked in real-time. "Moreover, humans can describe in words what they have just seen. They can also tell us what they are imagining or what they have just dreamt. It is almost impossible to get such information from a monkey." [8, p. 110]

In the course of a discussion, an experienced doctor or psychologist is able to obtain a very exact subjective diagnosis of a patient's condition; computer-aided tests and examinations serve to strengthen these subjective diagnoses.

Even more precise results can be achieved, if the researcher has access to all measurements and data of the patient's general information from genetic information, the molecular and cellular level, images from the structure and function, up to behavior in special designed neuropsychological tests in relation to the measurements. These data are still more useful when organised and analysed by a high-performance, properly programmed computer system in real-time. We name such strategy as Computer Aided Strategy since the beginning of the 70^th of the last century /www.ICSRoscher.de/RTV.htm/.

O3: Objective 3 of this project are meant to develop improved strategies for the recognition of the cause Alzheimer disease and of prevention of MCI and AD by the development of a Holistic Approach, is going from neuropathological strategies for diagnosis, genome information, molecular processes in and between cells to understand better the functioning and dysfunctioning of the brain up to access to actual publications around the world in order to combat such diseases and to better understand the ageing process, in order to develop the evidence base for improving health strategies to promote healthy living and healthy ageing. The project based on the results on the sequencing of the human genome and the post-genomic research and wants to improve human health.

O4: The Objective 4 is a multidisciplinary research for the design of a Holistic Approach for the recognition of Information Processes in natural and artificial systems. The strategy is designed from signals signal acquisition, into knowledge and the generation of reactions. The aim will be the recognition of the causes for the dysfunction of the Information Process in Mild Cognitive Impairments as first stage for Alzheimer disease. High performance networked computer systems designed as CA*S are used as model and for IA adapted to the needs and requirements of the physicians.