HUH
Dr. Hanna Rosenmann
Department of Neurology
Hadassah University Hospital
Ein Karem
Jerusalem 91120
Israel
Tel: 972-2-6776954
Fax: 972-3-7256022
rosenman@netvision.net.il, rosenman@hadassah.org.il

The Hadassah Medical Organization has three missions – to provide the best medical care, academic teaching and to conduct medical research. Its two hospitals serve as tertiary-care centers for the country. Its staff includes over 800 physicians (474 are Board Certified), 100 scientists, it has 1100 beds, a turnover of about 66,000 hospitalized patients and 320,000 outpatients per year.
Hadassah’s Hospitals embrace all the medical disciplines, world-known specialists and the newest diagnostic equipment.
At least 2/3 of Hadassah’s physicians have active interest in research, ranging from basic science to clinical applications, using the most modern facilities and lab equipment. The Organization also has exprect inter-departmental facilities for research which include, amongst others, a PET and a cyclotron unit, a transgenic animal facility, a GMP laboratory: for production of biologicals, a clinical trials center for phase I trials. The research is organized in departments and in inter-disciplinary research centers. Research funding is from national and international competitive not-for-profit funds, commercial and industrial investments, as well as from donations.
The availability of modern facilities equipped with the most state-of-the-art medical instrumentation used by highly motivated academic specialists, contribute to the high quality of medicine and research obtained at Hadassah.

Mrs. Dr. Hanna Rosenmann is specialized in molecular genetic and biochemical aspects of neurodegenerative diseases. In her PhD thesis in the Hadassah School of Medicine in the Hebrew University she worked on prion diseases as a model for neurodegeneration, and in her Post-doc on AD and related dementia. 
Since 1997- she is in charge of the Laboratory on Neurogenetics, in the department of Neurology, in the Hadassah University Hospital. The Laboratory of Neurogenetics includes: molecular genetic diagnosis of neurodegenerative disease, DNA bank of neurological diseases, and research of neurodegenerative disease with focus to AD and tauopathy (staff includes: technicians, MSC/PhD students, physicians on basic science projects). Since 2005 as an investigator /senior lecturer in the Hadassah School of Medicine in the Hebrew University, teaching in the department of Neurobiology.

Research areas:
1. Generating animal models for AD and tauopathies.
2. Genetic and environmental risk factors for AD and tauopathies.
3. Autoimmune aspects of AD and tauopathies.
4. Neurodegenerative and genetic aspects in other neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). 
5. Developing new neuroprotective therapeutic approaches against neurodegenerative disorders. 

References:

HUH1. Lossos A., Ekstein D., Soffer D., Gal A., Neheman Y., Reches A., Biran I., Meiner Z., Halimi M., Abramsky O., Rosenmann H. A P301S mutation in the tau gene in a Jewish- Algerian family affected by frontotemporal dementia and parkinsonism (FTDP). J. neurol. 250(6):733-740, 2003.

HUH2. Rosenmann H., Meiner Z., Kahana E., Aladjem Z., Friedman G., Ben-Yehuda A., Grenader T., Wertman E., Abramsky O. Polymorphism in the complement component C1r is not associated with sporadic Alzheimer’s diseases.  Neurosci. Lett. 336:101-104, 2003.

HUH3. Rosenmann H., Meiner Z., Kahana E., Aladjem Z., Friedman  G., Ben-Yehuda A., Grenader  T., Wertman E., Abramsky O. Genetic Variation in the pro-apoptotic gene p53  and the risk  for Alzheimer’s disease- no evidence for association. Neurosci. Lett. 340:29-32, 2003.

HUH4. Rosenmann H., Ginzburg I. Regulation of localization and phosphorylation of tau. 8th Alzheimer’s disease book of  proceedings, 287-301, 2003.

HUH5. Rosenmann  H., Meiner Z., Kahana E., Friedman G., Ben Yehuda A., Tal G., Wertman E., Abramsky O. The Fas promoter polymorphism at position – 670 is not  associated with late-sporadic Alzheimer’s disease. Dement. Geriatr. Cogn. Disord. 17:143-146, 2004.

HUH6. Rosenmann H., Meiner Z., Kahana E., Aladjem Z., Friedman  G., Ben-Yehuda A., Grenader T., Wertman E., Abramsky O. An association study of a polymorphism in the heparane sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer’s disease.   Am. J. med. Genet. (Neuropsychi Genet) 128B(1):123-125, 2004.

HUH7. Rosenmann  H., Meiner Z., Dresner-Pollak R., Kahana E., Tal G., Wertman  E., Abramsky O. Lack of association of a polymorphism in the IL-1B gene in the Jewish population. Neurosci. Lett. 363:131-133, 2004.

HUH8.  Rosenmann H.,  Meiner Z., Geylis V., Steinitz M. Naturraly occuring antibodies against unphosphorylated and phosphorylated tau protein in sera of AD and healthy subjects. Submitted 2005.

HUH9.  Rosenmann H., Grigoriadis H., Karussis  D., Mizrachi-Koll R.,  Boimel M., Touloumi O.,Haim Ovadia.., Oded Abramsky. Experimental Autoimmune Tauopathy: immunoreactivity against tau-microtubule-associated protein induces a neurological disease in mice. Submitted 2005. [Selected as a highlight study in 57th Annual Meeting of the American  Academy of  Neurology, Miami,  April 2005].   

HUH10. Rosenmann H., Grigoriadis N., Rozenstein L., Avraham Y., Touloumi O., Ginzburg I., Abramsky O. Neurofibrillary tangles and a spatial memory deficit in transgenic mice expressing P301S and K257T double mutant tau. [Selected as a  highlight study in 56th Annual Meeting of the American  Academy of  Neurology, San Francisco,  April 2004].