WIN
Prof. Irith Ginzburg 
Department of Neurobiology 
Weizmann Institute of Science 
Rehovot 76100
Israel. 
Tel: 972-89342799 
Fax: 972-89344131 
irith.ginzburg@weizmann.ac.il

 WIS - Weizmann Institute of Sciences

The Neurology Department (WIS) is a centre for high studies in life sciences in Israel. Our department is engaged in research around various topics in neurobiology. The topics of research in our department include (a) Neurodegenerative disorders both the clinical and the molecular research. AD, as well as other dementias (Prof. Irith Ginzburg). Collaboration with Prof, Oded Abramsky, Head of neurology department, Hadassa medical school Hebrew University, Jerusalem. Mutations in AD candidate genes (APP and Tau). AD animal models pathology and behaviour. (b) Neuroimaging analysis - MRI, fMRI, PET in collaboration with Ichilov Hospital Tel Aviv (Profs. R.Malach, A. Grinvald).  (c) Drug addiction (Prof Vogel). (d) Parkinson Disease (Prof. V. Teichberg). (e) Behavioral studies: long and short terms memory (Prof .Y. Dudai), (f) Pain (Dr. A. Zangen). (g) Nerve Regeneration, PNS and CNS (Prof. M. Schwartz). (h) Olfactory studies (Prof. E. Ahisar). (i) Electrophysiological studies on primary cultures derived from animal modes –AD, Parkinson, FMRP, Spinocerebellar ataxias (Prof. M. Segal).

The WIS has facilities for automated DNA sequencer, animal house, peptide synthesis, proteomics, and production of mono and poly antibodies. Our department has all the up to date facilities, and equipment required for the above-mentioned studies, including tissue culture rooms, biohazard tissue culture room for the use of viruses, and the fMRI facilities.

CV of the key person Mrs. Prof. Irith Ginzburg

Mrs. Prof. Irith Ginzburg is specialised in Molecular and cellular neurobiology related to the structure and function of neuronal cytoskeleton in normal and neurodegenerative conditions. The effect of BDNF on the expression of tau neuronal protein in P19 cells and the effect of tau abrogation by SiRNA on axonal outgrowth.

1985-2001         Associate Professor, The Weizmann Institute of Science, Department of Neurobiology

2002                 Full Professor, The Weizmann Institute of Science, Department of Neurobiology

1985-1986         Visiting Professor, Stanford University, Dept. of Neurobiology, USA.

1997                 Visiting Professor, Collège De France, Paris, France.

WIS1. Litman P, Barg J, Rindzoonski L, Ginzburg I. Subcellular localization of tau mRNA in differentiating neuronal cell culture: implications for neuronal polarity. Neuron. 1993,10(4):627-38.

WIS2. Rasouly D, Rahamim E, Ringel I, Ginzburg I, Muarakata C, Matsuda Y, Lazarovici P: Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of tau proteins. Mol Pharmacol. 1994 Jan;45(1):29-35.

WIS3. Pinter M, Aszodi A, Friedrich P, Ginzburg I. Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells. Neurosci Lett. 1994 Mar 28;170(1):91-3.

WIS4. Sadot E, Marx R, Barg J, Behar L, Ginzburg I. Complete sequence of 3'-untranslated region of Tau from rat central nervous system. Implications for mRNA heterogeneity. J. Cell Sci. 1995 Aug;108 ( Pt 8):2857-64.  

WIS5. Sadot E, Barg J, Rasouly D, Lazarovici P, Ginzburg I. Short- and long-term mechanisms of tau regulation in PC12 cells. J Cell Sci. 1995 Aug;108 ( Pt 8):2857-64.

WIS6. Fisher A, Heldman E, Gurwitz D, Haring R, Karton Y, Meshulam H, Pittel Z, Marciano D, Brandeis R, Sadot E, Barg Y, Pinkas-Kramarski R, Vogel Z, Ginzburg I, Treves TA, Verchovsky R, Klimowsky S, Korczyn AD. M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update. Ann N Y Acad Sci. 1996 Jan 17;777:189-96.              

WIS7. Sadot E, Gurwitz D, Barg J, Behar L, Ginzburg I, Fisher A.: Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells. J Neurochem. 1996 Feb;66(2):877-80.

WIS8. Aranda-Abreu GE, Behar L, Chung S, Furneaux H, Ginzburg I. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. J Neurosci. 1999 Aug 15;19(16):6907-17.

WIS9. Aronov S, Marx R, Ginzburg I. Identification of 3'UTR region implicated in tau mRNA stabilization in neuronal cells. J Mol Neurosci. 1999 Apr;12(2):131-45.

WIS10. Litman P, Behar L, Elisha Z, Yisraeli JK, Ginzburg I. Exogenous tau RNA is localized in oocytes: possible evidence for evolutionary conservation of localization mechanisms. Dev Biol. 1996 May 25;176(1):86-94

WIS11. Sadot E, Jaaro H, Seger R, Ginzburg I. Ras-signaling pathways: positive and negative regulation of tau expression in PC12 cells. J Neurochem. 1998 Jan;70(1):428-31.

WIS12. Heicklen-Klein A, Ginzburg I. speci Tau promoter confers neuronal ficity and binds Sp1 and AP-2. J Neurochem. 2000 Oct;75(4):1408-18.         

WIS13. Heicklen-Klein A, Aronov S, Ginzburg I.         Tau promoter activity in neuronally differentiated P19 cells. Brain Res. 2000 Aug 18;874(1):1-9.

WIS14. Aronov S, Aranda G, Behar L, Ginzburg I. Axonal tau mRNA localization coincides with tau protein in living neuronal cells and depends on axonal targeting signal. J Neurosci. 2001 Sep 1;21(17):6577-87.