| Network
of Excellence |
CARiMan |
The
Internet Portal for Computer Aided Risk Management |
Eng. Habeeb Karayanni
Researcher & Project Coordinator
The Galilee Society
Department : The Regional Research and Development Center
P.O.Box:437
Shefa-Amr 20200
Israel
T. : +972-4-9504523/4
Fax : +972-4-9504525
http://www.gal-soc.org
karayanni@gal-soc.org
The Galilee Society
is a leading Palestinian Arab non-partisan, community-wide, non-governmental
organization (NGO) located in Israel. It was established by four health care
professionals in 1981. The GS is
committed to the achievement of equitable health, environmental, and
socio-economic conditions and development opportunities for Palestinian Arab
citizens of Israel. The Galilee Society
operates its ongoing program by means of several professional departments:
Environment by following-up on environmental and human rights issues relating to
Israeli community and presenting those issues locally and internationally and working
to systematically address environmental issues facing the Galilee region.
Professional monitoring and litigation to isolate environmental hazards and
causes of health and environmental devastation, while avoiding new perils such
as Industrial zones and Stone Quarries that do not adhere to conditions of
environmental safety and citizens’ health.
Work in this field is either at the initiative of the department or in
coordination with local and national environmental organizations or aggrieved
groups. This field includes:
-
-Assessment
of resulting damage from the environmental hazard.
-
-Submitting
complaints to associated bodies.
-
-Impose
restrictions on factories and stone quarries to lessen environmental devastation
and force them to install pollution monitoring and filtering devices.
-
-Submit
complaints against polluters and use litigation to follow through on the
grievances.
The
Health Promotion and Education the Department focuses on issues of the Health
of the Palestinians in Israel and maintains ongoing collaboration with local institutes and universities
such as the ICDC, the Girtner Institute, The Hebrew University School of Public
Health, the health research groups at Ben Gurion University and Soroka Hospital
Objectives:
-
Creation
of an Arab Health Database.
-
Education
and knowledge dissemination.
-
Improving
the quality of life.
-
Health
development
-
Perform
research and health services
The
Negev where
Bedouin Arabs living in unrecognized villages represent one of the neediest
populations in Israel, with little access to even basic government services due
to their official “non-existence.” The GS focus has been on healthcare and
early childhood care.
Rikaz
Databank is a unique Internet information system, based on relational database
technology, for the storage, retrieval, and manipulation of up-to-date,
accurate, statistical data on the Palestinian minority in Israel.
The
Botanical Garden and Greenhouse (Al
Maissam) located in the Galilee village of Kafr Kanna.
This has become a regional center for the preservation of local plant
species and traditional Arab medicine, which also serves as a resource for
research, education and eco-tourism.
The
Regional Research and Development Center where
scientific research is conducted on health and environmental issues. The
Regional R&D Center is one of eleven R&D Centers officially recognized
by and eligible for financial support from the Ministry of Science in Israel. In
1999, it was ranked first by the Ministry of Science amongst the 11 Centers in
Israel. Ranking criteria include outstanding achievements, employment of
scientists, prior experience in scientific research, budgeting expertise and the
establishment of new facilities. The R&D Center scientists conduct
independent applied research in a wide range of fields including Environmental
Sciences and Engineering, Microbiology, Bioremediation, Molecular, Tumor and
Cell Biology, Bioinformatics and Genomics, Biofilm, Biochemistry, Plant
Pathology, Agriculture and Information Systems. Formally affiliated with Haifa
University, The Regional R&D Center maintains ongoing collaboration with
local and international research institutes and universities.
The Center’s Goals
-
Perform
applied research in areas of health, environment, agriculture, medicinal plants,
biotechnology and biology).
·
Improve and
develop health, environmental, economic and social conditions for the residents
of the region by attracting investors in applied scientific projects with
economic potential that develop from the work of the scientists in the various
areas.
·
Absorb
academics in various research fields and provide research funding from local and
international sources.
·
Develop a broad
array of scientific research programs for elementary and high school students in
the areas of science and biotechnology. Provide supervision for college and university students
completing their scientific studies.
Contribution to CARiMan:
Be
so kind and describe your intention to
-
your possible
contributions (from member of the Management Board as Project Manager,
Scientific Manager, JPA-Manager (Manager of the Joint Programme of Activity),
Workpackage Manager (WP-Manager) or contributions to JPA / WP
Possible
contribution as a Workpackage Manager (WP-Manager) and contribution to JPA/WP.
-
Description or
contribution to significant parts from B1…B10
Our
contribution to CARiMan in research activities to significant parts are as
follow:
B4.
Degree of integration and the joint programme of activities.
B4.1.
Integrating activities.
He: Application of CARiManS for health monitoring in risk situations.
Eh: Monitoring of environmental health risks.
En: Environmental CARiMan.
GR: Risk management in gene research and technology
Ac: Monitoring of Agricultural Crop Diseases and Pest Risks.
EC: CARiMan for risk management in project of the EC.
B.4.2
Programme for jointly executed research activities
PD: Portable devices, signal
conditioning and conversion
B.4.3
Activities to spread excellence
D1: Exchange of post-doc researchers, students, and experts
D2: Conferences, meetings and workshops
D3: Dissemination & Exploitation
D4: Publications
B.7
Organization and Management
B.8
Joint Programmer of Activities– first 18 months
-
Proposal for
new JPA / WP
1.
Biosensors
for Pathogenic Bacteria, and Viruses in the Environment
Standard
microbiological methods were established for determining whether water
contaminated with bacteria or not. A variety of simple culture-based tests,
which are intended to recover a wide range of microorganisms from water, are
collectively referred to as "heterotrophic plate count" or "HPC
test" procedures. There is no universal 'HPC measurement'. Although
standardized methods have been formalized, HPC test methods involve a wide
variety of test conditions that lead to a wide range of quantitative and
qualitative results. Temperatures employed range from around 20° to 40° C,
incubation times from a few hours to 7 days or a few weeks, and nutrient
conditions from low to high. The test itself does not specify the organisms that
are detected. Only a small proportion of the metabolically active microorganisms
present in a water sample may grow and be detected under any given set of HPC
test conditions, and the population recovered will differ significantly
according to the method used.
Bacteria
can respond to environmental stresses by activating there survival mechanisms,
Nutrient depletion stimulates a starvation response, which allows bacterial long
term persistence in nongrowing but culturable state (just in poor medium).
Recently, a numerous studies have been shown that bacteria that normally
culturable, can enter the nanculturable state when they subjected to prolonged
incubation in sterile water or soil. The
viable but Nonculturable State (VBNC) can escape detection by the standard
methods. Whether bacterial cells are alive or dead, or whether they are Starved
or VBNC state, is important when we have to make decisions related to such a
mater as safety of drinking water and food.
Nutrient-depleted
environments as such drinking water, cooling systems (air conditioners) can
induce a specific morphological changes to bacterial cells, and to the reduction
of bacterial size. Interaction of bacteria with interfaces like air-water and
/or solid water (Biofilm) induces in some bacterial species a reduction in cell
size. Some of the Vibrio and Pseudomonas strains had been reduced
their size upon interaction with air-water interfaces.
Very
small bacteria can be found in soil, seawater and freshwater. Multiple-nutrient
starvation decreases the cell volume of Vibrio cholera by as much as 85%
and this process can take place rapidly after starvation, and this response to
starvation is characteristic of many marine isolates as, Echerichia coli,
Pseudomonas aerugenosa, Vibrio cholera, flavobacterium and
others.
Our
aim to develop aptamer for sensors
for rapid identification of pathogens, using In vitro selection (1), or SELEX,
technique that allows the simultaneous screening of more than 10exp15 individual
nucleic acid molecules for different functionalities. This method is commonly
known as "in vitro selection", "in vitro evolution" or
"SELEX" (systematic evolution of ligands by exponential enrichment).
This novel technique is an extremely useful tool to screen for a particular
functionality, such as the binding to small organic molecules, large proteins,
bacteria and viruses or the alteration or de novo generation of ribozyme-catalysis.
Functional molecules or aptamers can be the basic recognition basis for
developing biosensors. The specificity of the aptamer to any pathogen is easily
determined by evolution of ligands that recognize species specific antigens of
any bacteria or virus.
Having
selected species specific DNA aptamer, immobilization on sensor surface
materials by physical absorption and attachment through chemical modification of
the DNA aptamers is will studied. Occupation of the entire sensor surface with
an even layer is of utmost importance to the operation of the sensor, as
non-specific binding would alter the signals from the sensor and give inaccurate
results (2).
Sensors
based upon acoustic wave transduction operate by sensing the mass of the analyst
bound to the sensor surface through an interaction with an elastic wave probe.
Acoustic transducers do not require that the analyst possess any special
properties such as optical, electrochemical or enzymatic activity. Acoustic wave
devices are therefore a class of transducer, which show considerable potential
for use in low cost sensors applicable to many types of assay.
1.
Specifity of Mnt master residue obtained from in vivo and in vitro selections. Silbaq
FS, Ruttenberg SE, , Stormo GD. Nucleic Acids Res. 30(24) 5539-5548 (2002)
2.
Probing Protein:DNA Interactions Using a Uniform Monolayer of DNA and Surface
Plasmon Resonance, by J. S. Shumaker-Parry, C. T. Campbell, G. D. Stormo, F.
S. Silbaq, R. H. Aebersold, in Scanning and Force Microscopies for
Biomedical Applications II, S. Nie, E. Tayima and E. S. Yeung, eds., Proceedings
of SPIE, Vol. 3922, 158-166 (2000).
2.
Integrating Biofeedback and Cognitive-Behavioral
Therapy for children with emotional and physical problems.
Our
clinic specializes in integrating Biofeedback and Cognitive-Behavioral Therapy
for children with emotional and physical problems.
We
will present our ideas for testing and implementing the monitoring technology
that will be developed.
Feasibility
Study
Objectives:
To test the ability to implement this technology with children of different
ages.
Methods:
Two age groups will be defined 8-12 and 14-18. Each group will consist of
20
volunteers (control group) and 20 children referred to our clinic.
They
will be asked to carry the sensors for 24 hours. Sensors can be: EHG, GSR (Sc),
HRV (heart rate variability), and breathing or peripheral temperature sensors.
Children
and there parents will be evaluated for different measures of compliance.
Clinical
Research
Objectives:
To
examine treatment carry-over.
Methods:
30 subjects will be recruited from our patient population. Physiological
baseline will be established during treatment sessions using one or all of the
following measures: EMG, GSR, HRV, and Temperature (for example EMG in the
trapezes before and after the session-progressive relaxation can also be
compared with autogenic relaxation or with CBT only).
Patients
will be monitored during the weekdays to check carry-over. They will be compared
to a group of children with no treatment at all that just had their baseline
measured in one session.
There
is great importance in all C.B.T therapies for exercising between sessions:
Objectives:
Based
on the technology enabling us to see psycho physiological measures in real time
from distance, to check whether it is possible to correct children while they
are training in self-regulation skills at home.
Method:
30 patients will be monitored between sessions at agreed time. Child will call
therapist and will perform relaxation exercise therapist will give instructions
on real time based on F.B to improve and correct the child.
Objective:
To check the ability to function as a portable biofeedback devise giving the
child an audio/other sensory modality feedback if he actives or passes a
pre-determined threshold (EMG, GSR, Temp.). Such a device could help a child
modulate his psychology in real time.
Sensing
Deep Depression through EHG, GSR (Sc), HRV and breathing or peripheral
temperature - Does it work?
Objectives:
To test the ability of these sensors for diagnoses of depression by implementing
the previously mentioned technology with a specific group of young women at the
Galilee.
Methods:
Two age groups will be defined 13-18 and 19-24. Each group will consist of
20
volunteers (control group) and well recognized group (20)
at a specific village at the Galilee, selected according to the following
criteria (symptoms): young women
between 13 -24 dropped-out from schools are at home taking care of the
household. At home, these women are subject to domestic physical abuse; suffer
also from overweight and self neglect. The little information about this
violence is reported to social workers or psychologists through friends of the
victims only after they try to commit suicide. The solicitation of specialists
in this late stage hinders taking preventive measures.
Description
of the Partner:
The primary purpose of the Center is to improve the life course of
children and adolescents in Israel. This
objective will be achieved by: (1) Maintaining and extending the present
excellent mental health clinical services provided to children at SCMCI; (2)
conducting research studies on the prevention of psychiatric and emotional
illnesses, (3) developing and implementing research projects on early
intervention and effective treatment of children and adolescents with emotional,
behavioral, and developmental disorders, and (4) providing education and
training to the next generation of talented professionals in order to advance
both research and knowledge of developmental psychopathology. The ultimate objective of the Feinberg Child Study Center, in
collaboration with Tel Aviv University, Geha Psychiatric Hospital, Yale
University, and other research and clinical facilities in Israel and abroad, is
to be ranked as a world-class leader in child and adolescent psychiatric
treatment and research.
The
creation of the Center has been responsive to four factors.
The first factor concerns the serious burden of emotional, behavioral,
and developmental disorders among children and adolescents in Israel. While the rate of these disorders approximates 8 to 12%
throughout the world, in past years Israel had relatively lower rates of such
disorders. However, in recent years
the rate of these conditions has been increasing in Israel, and as a consequence
the mental health of Israeli youth and their families has become a serious
concern. Israel has witnessed
increased rates of suicide and suicidal behavior, substance abuse, and violent
crime among its youth, as well as more negative social indicators that are often
precursors to such conditions, including family dysfunction resulting in divorce
and child and parental abuse. In addition to these factors the unsettled
security situation and the rise of political violence in our region has led to a
disturbing rise in the incidence of many disorders such as anxiety and
depression in our country.
A second factor is the international recognition of the paucity of
research into the causes and treatments of such difficulties that has resulted
in the current inability to deal more effectively with these worrisome social
trends. The third factor recognizes
that there are a limited number of researchers with the requisite skills to
address these problems. Thus, the
training of the next generation of researchers is critical to ultimately
improving the life course of at-risk youth.
The Center proposes to contribute to the development of a critical mass
of researchers who will work together in an interdisciplinary fashion to deal
with the complex problems facing Israeli youth.
Fourth, the Center aims to coordinate research among a large network of
institutions in Israel and abroad in order to maximally involve existing
resources and in doing so to increase the probabilities of competing
successfully for external funding. The
Center will continue and endeavor to expand extensive collaborations with the
Yale University Child Study Center, the Western Psychiatric Institute,
University of Pittsburgh Medical School, the Karolinska Institute, Stockholm
Sweden and other
internationally renowned research institutions.
The basic philosophy of the Center is to combine the traditional humane
approach underlying all the mental health disciplines with innovative modern
medical science. When possible and
appropriate, treatment and research will be maximally integrated. In addition, the Center will be involved with advocacy and
public health education in collaboration with local municipal councils, welfare
organizations, and institutions for the developmentally disabled.
The major assets of the Feinberg Child Study Center include the high
quality faculty and the cadre of young mental health professionals who have made
a career commitment to child and adolescent mental health. The number of
talented trainees committed to clinical research is unique and these
professionals will contribute significantly to the capacity of the Center to
conduct research and train the next generation of researchers.
Because of the close connection between clinic and research, the access
to research subjects, even of relatively rare conditions like first-break
suicide or schizophrenia, allows for studies to be conducted that are virtually
impossible in most American and European research centers. Moreover, the Center
carries out scientific endeavors in the areas of child and adolescent
psychiatry, fosters close collaborations with national and international
colleagues, and has special access to clinical and epidemiological population
samples.
3
.
Long-term research project on the Genetic health diversity of the
Palestinians in Israel: survey, observe and consign a mechanism for disease
prediction.
The
Palestinian community in Israel which constitutes 20% of the population (about
one million) is one of the most diverse and complex communities with regard to
its genetic pool. This arises from the following primary factors:
-
Palestine,
with its geography, history and civilization was a terminus for many consecutive
nations during centuries, which made the Palestinian community descendants of
many races that intermixed and mingled throughout history leading to the rise of
genetic diversity (multi-allelic) that survived due to the moderate natural
climate in Palestine that allowed most of the strains to adjust.
-
The
Palestinian community in Israel can be considered an isolated closed society
apart from the Palestinian people and the other neighboring Arab communities for
over fifty years due to political circumstances. This isolation has led to importunate demand on the
genetic pool of this community.
-
This
demand on the genetic pool in the Palestinian community in Israel becomes acute
if we consider the division of the community into three religious groups
(Muslims, Christians, and Druze) as intermarriage between these three groups is
very rare leaving the genetic pool depleted and we find ourselves studying a
complex community (sub-genetic pools).
-
Another
level of the differentiation that caused the strain on the genetic pool arises
from the division of the Palestinian community in Israel in the most part to
residents of rural areas (in the Galilee and the Triangle) and residents of the
Bedouin population (concentrated in the Negev Desert area).
Intermarriage is rare between these groups for geographical and social
considerations.
-
The
Palestinian community in Israel is mainly rural in nature, where family and clan
relations are strong, and commitment to social norms is intense, including the
encouragement of inter-relative marriage.
Determining
criteria and signals to be monitored:
Objectives:
To determine which criteria and signals to be monitored.
The
Palestinian community in Israel can represent a most efficient case study for
determining criteria and signals to be monitored then determining which signals
should be followed up by sensors. In such research projects, the long time
consuming step is the selection of the study group. The selection of the well
defined study group would be almost saved due to natural selection of a wide
genotypic diversity expressed phenotypically. Based on the high diversity among
Arabs in Israel, it is possible to survey; monitor and follow-up the health
situation of individuals on the basis of their family relations, because
the differentiation within the community is substantial that genetic/health
differences are evident between a village and its neighbor or between two
families in the same village. For
example, there are families that suffer from diabetes or cardiovascular
diseases, family related pregnant blood pressure or hereditary diseases in
averages higher than the standard, in addition to developmental diseases that
delay fetuses development.
Using
a computer program that takes into consideration all the above-mentioned factors
and connects between the degree of family kinship, type of disease and family
health history, we can limit and pursue the appearance of a specific disease in
the family. It is also possible to
designate specific genetic indicators that relate to the incidence of the
"family" disease in the future.
Therefore,
a complete methodological research project to survey the health status of the
Palestinian community in Israel will result in a great amount of knowledge on
genetic-health diversity (genotype level) of humans with concentrated diversity
in a society that is limited numerically and extremely complex in its genetic
makeup health-wise, socially, and historically.
Short description of the organisation
The
Regional Research and Development Center where scientific research is conducted on environmental and health
issues. The Regional R&D Center is one of eleven R&D Centers officially
recognized by and eligible for financial support from the Ministry of Science in
Israel. In 1999, it was ranked first by the Ministry of Science amongst the 11
Centers in Israel. The R&D Center scientists conduct independent applied
research in a wide range of fields including Environmental Sciences and
Engineering, Microbiology, Bioremediation, Molecular, Tumor and Cell Biology,
Bioinformatics and Genomics, Biofilm, Biochemistry, Plant Pathology, Agriculture
and Information Systems. Formally affiliated with Haifa University, The Regional
R&D Center maintains ongoing collaboration with local and international
research institutes and universities.
CV of the partners
Publications
1. Mor N; Resnick M; Silbaq F; Bercovier H; Levy L .1988.
Reduction of tellurite and deesterification of fluorescein diacetate are not
well correlated with the viability of mycobacteria. . Ann Inst Pasteur Microbiol,
139(3):279-288 .
2. Silbaq F; Levy L; Bercovier H. 1989. Doubling time of
Mycobacterium lepraemurium in mouse footpads.
Res Microbiol, 140(1):43-50.
3. Silbaq F; Mor N; Levy L; Bercovier H.1990.
The disease of CBA and BALB/c mice that follows inoculation of a small
number of Mycobacterium lepraemurium into the hind foot pad. Int J Lepr Other
Mycobact Dis, 58(4):681-689.
4. Silbaq F, Bercovier H. 1993. Nucleotide sequence of
Mycobacterium leprae elongation factor (EF-Tu) gene. Nucleic Acids Res
11;21(14):3327
5. Rahav G, Pinco E, Silbaq F, Bercovier H. 1994. Molecular
epidemiology of catheter-associated bacteriuria in nursing home patients. J Clin
Microbio 32(4):1031-4
6. Silbaq FS, Cho SN, Cole ST, Brennan PJ. 1998. Characterization
of a 34-kilodalton protein of Mycobacterium leprae that is isologous to the
immunodominant 34-kilodalton antigen of Mycobacterium paratuberculosis. Infect
Immun ;66(11):5576-9
7. Eckstein TM, Silbaq FS, Chatterjee D, Kelly NJ, Brennan PJ,
Belisle JT. 1998. Identification and recombinant expression of a Mycobacterium
avium rhamnosyltransferase gene (rtfA) involved in glycopeptidolipid
biosynthesis. J Bacteriol ;180(21):5567-73
8. Probing Protein:DNA Interactions Using a Uniform Monolayer of DNA
and Surface Plasmon Resonance, by J. S. Shumaker-Parry, C. T. Campbell, G. D.
Stormo, F. S. Silbaq, R. H. Aebersold, in Scanning and Force Microscopies
for Biomedical Applications II, S. Nie, E. Tayima and E. S. Yeung, eds.,
Proceedings of SPIE, Vol. 3922, 158-166 (2000).
9. Silbaq FS, Ruttenberg SE, , Stormo GD. 2002. Specifity of Mnt
master residue obtained from in vivo and in vitro selections. Nucleic Acids Res.
30(24) 5539-5548
10. Silbaq FS, Stormo GD, 2002. In vitro selection of DNA binding
sites for wild-type and mutants Mnt repressor. Nucleic Acids Res. In press
1.
A. Apter and L.A.
Hurst
Personality and peptic ulcer
South African Medical Journal, 47(44): 2131‑2133, 1973.
2.
A. Apter, S. Tyano and H. Wijsenbeek
Dimensions of adolescent in‑patient behavior. Acta
Psychiatrica Scandinavica, 53: 277‑282, 1976.
3.
D. Lombroso, S. Tyano and A. Apter
Attitudes of Israeli adolescents to the mentally ill and their
treatment.
Israel Annals of Psychiatry, 14(2): 120‑132, 1976.
4.
B. Maoz, A. Antonowsky, A. Apter, H. Wijsenbeek and N. Datan
The perception of menopause in five ethnic groups in Israel.
Acta
Obstet. Gynecol. Scand.
Suppl. 65: 69‑76, 1977.
5.
B. Maoz, A. Antonowsky, A. Apter, N. Datan, J. Hochberg and
Y. Salomon The effect of outside work on the menopausal woman. Maturitas,
1:43‑53, 1978.
6.
B. Maoz, A. Antonowsky, A. Apter, H. Wijsenbeek and N. Datan
Ethnicity and adaptation to climacterium.
Arch. Gynakologie, 223: 9‑18, 1977.
7.
A. Apter, S. Tyano, D. Lombroso, H. Wijsenbeek and E. Chiger
Sex education on an adolescent in‑patient ward.
Israel Rehabilitation Annual, 14: 96‑101, 1977.
8.
A. Apter, G. Moran, S. Tyano, H. Munitz, B. Maoz and H. Wijsenbeek
The psychosocial sequela of the Milwaukee brace in adolescent girls. Clinical
Orthopaedics and Related Research, 13: 155‑159, 1978.
9.
A. Apter, I. Sharir, S. Tyano and H. Wijsenbeek
Movement therapy with psychotic adolescents. Brit. J. Med. Psychol.,
51: 155‑159, 1978.
10.
I. Modai, A. Apter, M. Golomb and H. Wijsenbeek M.H.P.G.
and response to amitriptyline in bipolar depressed patients.
Neuropsychobiology, 5: 181‑184, 1979.
11.
A. Apter, A. Galatzer, N. Beth Halachmi and Z. Laron
Self image in adolescents with delayed puberty and growth
retardation.
J. Youth Adolescence, 10(6): 501‑505, 1981.
12.
A. Apter, M.A. Borengasser, J. Hamovit, J. Bartko, L. Cytryn and D.H.
McKnew, Jr.
A four‑year follow up of depressed children.
J.
Prevent. Psychiat.,
1: 469‑470, 1982.
13.
D. McKnew, L. Cytryn, M. Lamour and A. Apter Fantasy in childhood depression and other forms of
psychopathology.
J.
Adolescent Psychiatry, 10: 292‑298, 1982.
14.
A. Apter, Z. Dickerman, N. Gonen, S. Tyano and S. Laron
Hypothalamic gonadal axis in schizophrenic male adolescents.
Am. J. Psychiatry, 140(12): 1588‑1591, 1983.
15.
A. Apter, A. Blum and N. Skurnik
Reaction psychomatique a un stress continu.
Annales Medico‑Physiologiques, Paris, 7: 798‑802, 1983.
16.
D. Wigiser, A. Apter, U. Aviram and B. Maoz Over utilization of the emergency room by psychiatric
referrals.
Am. J. Public Health, 74(1): 73‑75, 1984.
17.
A. Apter, E. Bernout and S. Tyano
Severe obsessive compulsive disorder in adolescence:
A report of eight cases. J. Adolescence, 7: 349‑358, 1984.
18.
A. Ram, A. Apter, A. Weizman, H. Kaufman and S. Tyano
Dexamethasone suppression test in psychiatrically hospitalized
adolescents.
Harefuah ‑ J. Israel Med. Assoc., CVVI(3‑4): 72‑74,
1984.
19.
M. Rehavi, R. Weizman, C. Carel, A. Apter and S. Tyano High-affinity
3H-imipramine binding in platelets of children and adolescents with major
affective disorder Psychiatric Research 13, 31-39
20.
R. Weizman, M. Carmi, S. Tyano, A. Apter and M. Rehavi
High affinity 3H imipramine binding and serotonin uptake to
platelets
of adolescent females suffering from anorexia nervosa.
Life Sciences, 38: 1235‑1242, 1986.
21.
A. Weizman, M. Carmi, H. Hermesh, A. Shahar, A. Apter, S. Tyano and M.
Rehavi High affinity imipramine
binding and serotonin uptake in platelets of eight adolescents and ten adults
obsessive compulsive patients. Amer. J. Psychiatry, 143(3): 335‑339, 1986.
22.
Z. Zemishlany, I. Modai, A. Apter, Z. Yerushalmi and S. Tyano
Serotonin uptake in platelets of patients with anorexia nervosa. Acta Psychiatr. Scand.,
75: 127‑130, 1987.
23.
Y. Kronenberg, R. Blumensohn and A. Apter A comparison of different
diagnostic tools for childhood depression. Acta
Psychiatr. Scand.,
77(2): 194‑198, 1987.
24.
Y. Kaminer, A. Apter, A. Aviv, P. Lerman and S. Tyano
Psychopathology and temporal lobe epilepsy in adolescents.
Acta
Psychiatr. Scand.,
77: 640‑644, 1988.
25.
A. Apter, R. Offer, R. Blumensohn and S. Tyano Use
of the Child Behavior Checklist in an Israeli adolescent psychiatric unit. Acta Psychiatr. Scand.,
78: 96‑101, 1988.
26.
A. Apter, A. Bleich and S. Tyano Affective and psychotic psychopathology
in hospitalized adolescents.
J. Am. Acad. Child Adolesc. Psychiatry, 27: 116‑120, 1988.
27.
A. Apter, A. Bleich, R. Plutchik, S. Mendelsohn and S. Tyano
Depression, suicidality and conduct disorder. J. Am. Acad. Child
Adolesc. Psychiatry , 27(6): 696‑699, 1988.
28.
A. Apter and S. Tyano Obsessive compulsive disorder in adolescence.J.Adolesc.,11:
183‑194, 1988.
29.
G. Ratzoni, A. Apter, R. Blumensohn and S. Tyano Suicidal behavior in
Ethiopian adolescents.J. Adolesc. 11: 231‑236, 1988.
30.
A. Apter, H. Orvaschel, M. Laseg, T. Moses and S. Tyano
Psychometric properties of the K‑SADS‑P in an Israeli
adolescent psychiatric population. J. Am. Acad. Child Adolesc. Psychiatr.,
28(1):
61‑65, 1989.
31.
A. Apter, R. Plutchik, S. Sevy, M. Korn, S. Brown and
H.M. van Praag Defense mechanisms in risk of suicide and risk of
violence.
Am. J. Psychiatry, 146: 1027‑1031, 1989.
32.
I. Modai, A. Apter, M. Meltzer, S. Tyano, A. Valewski and Z. Jerushalmy
Serotonin uptake by platelets of suicidal and aggressive adolescent
psychiatric inpatients.
Neuropsychobiology. 21:
9‑13, 1989.
33.
A. Biegon, A. Grinspoon, B. Blumenfeld, A. Bleich, A. Apter and
R. Mester Serotonin 5‑HT2 receptor binding on blood platelets of
suicidal and non suicidal men.
Psychopharmacology, 100: 165‑167, 1989.
34.
A. Apter, H.M. van Praag, S. Sevy, M. Korn and S. Brown
Interrelationships among anxiety, aggression, impulsiveness and mood:
A serotonergically linked cluster? Psychiatric Research,
32:191‑199, 1990.
35.
G. Ratzoni, R. Blumenson R, A. Apter, S. Tyano. The Psychiatric Treatment
of Ethiopian Adolescents. Israel Journal of Medical Science.
36.
I. Orbach, I. Milstein, S. Tyano,
D. Hareven, A. Apter,
S Tyano, A. Elitzur A
(1991) Multi‑attitude suicide tendency scale for adolescents. J.
Consulting & Clinical Psychology
3:3, 398-404.
37.
A. Apter, B. Spivack, A Weizman, S Tyano and Orvaschel H. Paranoid
schizophrenia in adolescence. Journal of Clinical Psychiatry September
365-368. 1991
38.
A. Apter, M. Kotler, S. Sevy, R. Plutchik, S. Brown, H.Foster, M.
Hillbrand, M. Korn, H van Praag. Correlates of risk of suicide in violent and
nonviolent psychiatric patients. American Journal of Psychiatry 148 (7)
883-887. 1991
39.
Apter A., Aviv A., Kaminer Y., Weizmann A., Lerman P and Tyano S.
Behavioral profile and social competence of adolescents with temporal lobe
epilepsy. Journal of the American Academy of Child and Adolescent Psychiatry.
30,6:887-892, 1991.
40.
M. Koslowsky, A. Bleich, A. Greenspoon, B. Wagner, A. Apter and Z.
Solomon Assessing the validity of
the of the Plutchik Suicide Risk Scale. J Psychiatr Res 25(4)155-8, 1991.
41.
A. Walevsky, I. Gil-Ad, I. Modai, A. Apter, Z Laron and A Weizman
Neuroendocrine response to trihexyphenidyl in depressed patients. Clin
Neuropharmacol. 15:(1) 27-33, 1992.
42.
M. Skuy, A. Apter, Y. Dembo, S. Tyano, S. Kaniel and D. Tsuriel Cognitive
modifiability of adolescents with schizophrenia.
British Journal of Child Psychology and Psychiatry. 33,3,583-589 1992
43.
R. Tepper, A. Weizman, A. Apter, Tyano S. and Y. Beyth. Elevated plasma
immunoreactive B-endorphin in anorexia nervosa Clinical Neuropharmacology
15,5.387-391, 1992
44.
Z. Scheinberg, A. Bleich, M Koslovsky, A Apter, M. Mark, I. Barbur, M.
Kotler, Y.I. Danon Prevalence of
eating disorders among female Israel Defense Force recruits. Harefuah Journal
of the Israel Medical Association 123, 3-4, 73-78, 1992.
45.
M. Koslowsky, A. Bleich, A. Apter, Z. Solomon, B. Wagner and A.
Greenspoon. Structural equation modelling of some determinants of suicide risk. British
Journal of Medical Psychology 65,157-165, 1992.
46.
S. Tyano and A. Apter Adolescent
psychosis-an eight year follow up. Journal of Adolescent Psychiatry
317-324, 1992
47.
M. Koslowsky, Z. Scheinberg, A. Bleich, M. Mark, A. Apter, Y Danon, Z.
Solomon The factor structure and
criterion validity of the short form of the Eating Attitudes Test. J Pers
Assessment 58(1):27-35, 1992
48.
A. Zohar, G. Ratzoni, D. Pauls, A. Apter A. Bleich, S. Kron, M. Rappaport,
A. Weizman and D. Cohen An epidemiological study of obssessive compulsive
disorder and related disorders in Israeli adolescents J. Am. Acad. of Child
and Adolesc.Psychiatry 31:6; 1057-1061, 1992.
49.
A. Apter, D. Pauls, A. Bleich, A. Zohar, S. Kron, G. Ratzoni, A. Dycian,
M. Kotler, A. Weizman and D. Cohen. A population-based study of Tourette
syndrome among adolescents in Israel. Advances in Neurology 58:61-65,
1992.
50.
A. Apter, R. Plutchik, and
H.M. van Praag. Anxiety, impulsivity and depressed mood in relation to suicide
and violent behavior.
Acta
Psychiatrica Scandinavica.
87 (1):
1-5. 1993
51.
A.Apter, A. Bleich, R. King, S. Kron, A. Fluch, M. Kotler, D. Cohen.
Death without warning? A clinical postmortem study of 43 Israeli male suicides. Archives
of General Psychiatry 50;138-142, 1993
52.
G. Ratzoni, I. Mann, T. Weizman, A. Weizman, I. Modai and A. Apter
Psychiatric hospitalization of Ethiopian adolescents. Israel Journal
of Medical Science 29 :419-421, 1993
53.
Bessler H, Karp L, Notti I, Apter A, Tyano S, Djaldetti M, Weizman R
Cytokine production in anorexia nervosa Clinical Neuropharmacology
16 (3) 237-243, 1993
54.
R. Weizman, D. Dar, S. Landa, A Apter and M. Gavish
"Peripheral" benzodiazepine receptor density is not altered by
methylphenidate treatment in children with attention-deficit hyperactivity
disorder Journal of Child and
Adolescent Psychopharmacology 3 (2) 63-69, 1993
55.
A. Apter, D. Pauls, A Bleich, A. Zohar S. Kron, G. Ratzoni, A Dycian, M.
Kotler, A. Weizman, N. Gadot, D. Cohen. An epidemiological study of Gilles de la
Tourette's syndrome in Israel Archives of General Psychiatry 50:
734-738, 1993
56.
I. Orbach, P. Kedem, O. Gorchover, A. Apter and S. Tyano Fears of death
in suicidal and non suicidal adolescents Journal of Abnormal Psychology
102 (4) 553-558, 1993
57.
A. Apter, M. Abu-Shah, I. Iancu, H. Abromovitch, A. Weizman and S. Tyano.
Cultural effects on eating attitudes in Israeli subpopulations and hospitalized
anorectics Genetic, Social and General Psychology Monographs 120 (1)
85-99, 1994.
58.
M. Koslowsky, Z Scheinberg, A Bleich, M Mark, A Apter, Y Danon, Z.
Salomon, I Barbur. Sensitivity, specificity, and positive predictive value as
measures of prediction accuracy: The case of the EAT-26 Educational and
Psychological Measurement 53; 831-839.
59.
M. Koslowsky, Z Scheinberg, A Bleich, M Mark, A Apter, Y Danon, Z.
Salomon, I Barbur. Predicting actual weight from self report data. Educational
and Psychological Measurement 54; (1) 168-173. 1994
60.
A Apter, G. Ratzoni, R. King, A Weizman, I Iancu and M. Riddle
trial of fluvoxamine in adolescent psychiatric inpatients
J. Am. Acad. of Child and Adolesc.Psychiatry
33:3:342-348, 1994.
61.
A. Grinspoon, M. Mark, A. Apter I. Modai, A. Bleich, M. Rehavi, and A.
Weizman. Failure of fixed dose
verapamil treatment in adult sleep enuresis European Journal of Psychiatry.9,
101-103, 1994.
62.
A. Apter, A Gallatzer, A. Weizman, T. Weizman and Z. Laron Psychological
aspects of developmental endocrinopathies in adolescence Israel Journal of
Psychiatry 31, 4, 246-253, 1994.
63.
B Spivak, N Kosower, Y Zipser, N Schreiber-Schul, A Apter, S Tyano and A
Weizman. Platelet Monoamine Oxidase activity in neuroleptic naive schizophrenic
patients: lack of influence of chronic phenelzine treatment Clinical
Neuropharmacology, 17:83-88, 1995.
64.
N Horesh, A. Apter, E. Lefkifker, G. Ratzoni, R. Weizman and S.Tyano.
Life events and anorexia nervosa Acta Psychiatrica Scandinavica
91:(1):5-9, 1995.
65.
Apter A., Gothelf D., Orbach I., Har-Even D., R. Weizman and S. Tyano
Correlation of suicidal and violent behavior in different diagnostic categories
in hospitalized adolescent patients. J. Am. Acad. of Child and
Adolesc.Psychiatry 34, 7:912-918 1995.
66
R. Blumensohn, G.Ratzoni, A. Weizman, M. Israeli, N. Greuner, A. Apter S.
Tyano and A. Biegon. Reduction in serotonin 5HT2 receptor binding on platelets
of delinquent adolescents Psychopharmacology 118:354-356, 1995.
67.
R. A. King, A. H. Zohar, G. Ratzoni, M. Binder, S. Kron, A.
Dycian, D.J. Cohen, D.L. Pauls
A. Apter,. An epidemiological study of trichotillomania in Israeli
adolescents. J. Am. Acad. of Child and Adolesc.Psychiatry 34:9, 1212-1215
1995.
68
D. Gothelf, A. Apter, G. Ratzoni, R. Weitzman, I.Orbach, S. Tyano and C.
Pfeffer. Defense mechanisms in severe anorexia nervosa
J. Am. Acad. of Child and Adolesc.Psychiatry
34:12 1648-1654 1995.
69.
Orbach I, Kedem P, Herman L and Apter A. Dissociation tendencies in
suicidal adolescents J. Social and Clinical Psychology 14:4;393-408,
1995.
70.
Goren A, Fine J, Manaim H and Apter A,
Verbal and non-verbal expressions of central deficits in schizophrenia. The
Journal of Nervous and Mental Disease.183, 11, 715-719.
71.
Ohring R., Apter, A., Ratzoni G., Weizman R., Tyano,S. and Plutchik R.
State and Trait anxiety in adolescent suicide attempters. J. Am. Acad. of
Child and Adolesc.Psychiatry 35(2)154-157, 1996.
72.
Apter A., Fallon T.,
Ratzoni G., Binder M., Kron S., Dycian
A., King RA., Zohar A., Weizman A.,
Pauls D., Cohen D., Obsessions and compulsions: from symptoms to syndrome J. Am. Acad. of Child and Adolesc.Psychiatry
35 (7) 921-927, 1996.
73.
Horesh N., Apter A., Ishai J., Miculincer M., Danziger Y and
Mimouni M. Abnormal psychosocial factors and anorexia nervosa J. Am.
Acad. of Child and Adolesc.Psychiatry 35 (7) 907-912, 1996.
74.
Horesh N, Rolnick T, Iancu I, Danon P, Lefkifker E, Apter A and Kotler M,
Acta Psychiatrica Scandinavica 93, 489-493 1996.
75
King RA and Apter A
Psychoanalytic perspectives on adolescent suicide. Psychoanalytic Study of
the Child 51:491-505 1996.
76.
Spivak B, Karny N, Katz G, Radwan M, Apter A, Mester, R and Weizman A:
Functional hemisphere imbalance in patients with paranoid or disorganized
schizophrenia. Eur. Psychiatry 11:175:175-179, 1996.
77.
Zohar A.H., Pauls, D. Apter A. , Binder, M., Weizman, A., Kron S., Dycian,
A., King, R., Cohen, D. OCD with and without tics in an epidemiological sample
of Israeli adolescents: Are they distinct subtypes. American Journal of
Psychiatry 154:274-276, 1997.
78.
Gothelf G, Apter A and Van Praag H: The measurement of aggression in
psychiatric patients Psychiatry Research 71, 83-95,
1997.
79.
Iancu I, Laufer, N., Danon PN, Kadosch-Zohar R, Apter A, Zohar J. A
general hospital study of attempted suicide in adolescence: Age and method of
attempt Israel Journal of Psychiatry 34 (3) 228-234 1997
80.
Apter, A., Offer R., Gothelf, D., Plutchik, R. and Pfeffer, C. Defense
mechanisms in suicidal adolescents J. Am. Acad. of Child and Adolesc.
Psychiatry 36
(11):1520-1527.1997
81.
Shanee N., Apter A., Weizman A. The psychometric properties of the K_SADS-PL
in an Israeli adolescent clinical population Israel Journal of Psychiatry
34(12) 179-186.1997.
82.
Horesh N, Rolnick T, Iancu I, Danon P, Lefkifker E, Apter
A and Kotler M: Anger, Anxiety
and suicide risk. Psychotherapy and Psychosomatics 66 92-96, 1997.
83.
Cohen Y., Spirito A., Apter A and Saini S. A cross cultural comparison of
behavior disturbance among psychiatrically hospitalized adolescents in Israel
and the United States Child Psychiatry and Human Development 28(2):89-102
1997.
84.
Stein D., Apter A., Ratzoni
G., Har-Even D. and Avidan G. Association between multiple suicide attempts and
negative affects in adolescence. J. Am. Acad. of Child and Adolesc.
Psychiatry 37, 5,488-494. 1998
85.
Katz N. Gothelf D., Hermesh H., Weizman A., Apter A and Horev G. Bone age
in adolescents with schizophrenia and obsessive compulsive disorder Schizophrenia
Research 33, 119-132 1998
86.
Golan M., Weizman A., Apter A and Fainaru. M. Parents as the exclusive
agents of change in obesity. American Journal of Clinical nutrition 67(6)
1130 1998
87.
Gothelf D, Apter A, Gothelf A, Offer N, Ofek H, Tyano S and Pfeffer C.
Death concepts in suicidal adolescents J. Am. Acad. of Child and Adolesc.
Psychiatry 37,12 1279-1286, 1998
88.
Ofek H, Weizman T and Apter A. The
Child Suicide Potential Scale. Inter-rater reliability and validity in Israeli
in-patient adolescents. Israel Journal of Psychiatry 35, 4, 253-261, 1998
89.
Schmidtke A., Weinacker B., Apter A et al., Suicide rates in the world Archives
of Suicide Research 5: 81-89, 1999
90
Horesh N, Gothelf D, Ofek H and A Apter, Impulsivity as a correlate of
suicidal behavior in adolescent psychiatric inpatients. Crisis 20,1: 8-14
1999
91.
Sireni N and Apter A. GABA and suicidal behavior in adolescence. Biological
Psychiatry 46 (4) 484-488 1999
92.
Apter A., Laufer N., Bar-Sever M., Har-Even D., Ofek H., Weizman A. Serum
cholesterol, Impulsivity, aggression and depression in adolescent inpatients Biological
Psychiatry 532-541 1999
93.
Geijer T., Frisch A., Persson ML., Wasserman D. Rokah R., Michaelowsky E., Apter
A Jonsson EG. Nothen MM. Weizman A Lack of an association between suicide
attempt and a polymorphism at the dopamine D4 locus. Psychiatric Genetics 9:97-100
1999
94.
Offer R., Lavie R., Gothelf D. and Apter A. Defense Mechanisms, Negative
emotions and psychopathology in adolescent inpatients Comprehensive
Psychiatry 41 (1) 35-41 2000
95
Geijer T., Frisch A., Persson ML., Wasserman D. Rokah R., Michaelowsky E.,
Jonsson EG. Apter A and Weizman: Search for association between suicide
attempt and serotonergic polymorphism. Psychiatric Genetics 10: 19-26
2000
96
Zalsman G, Natanel R, Fischel Z, Freudenstein O, Landau, E, Orbach I, Weizman A,
Pfeffer C, Apter A The human figure drawing in the evaluation of severe
adolescent suicidal behavior J. Am Acad. Child Adol. Psychiatry 39:1024-31
2000
97
Perrson ML, Wasserman D, Geijer T, Frisch A, Rocah R, Michaelovsky E, Apter A
Weizman A, Jonsson EG, Bergman H Dopamine D4 receptor gene polymorphism and
personality traits in healthy volunteers Eur. Arch Psychiatry and Clin.
Neurosci 250 (4) 203-6 2000
98
Frisch A, Laufer N Danziger Y, Michalovsky E, Leor S, Carel C, Stein D, Fenig ,
Mimouni M, Apter A and Weizman A Association of the anorexia nervosa with
a high activity COMT gene: a family based study in Israeli patients Molecular
Psychiatry 6 243-245 2001
99
Zalsman G, Frisch A, Bromberg M, Gelertner J, Michaelowsky E, Campino A, Erlich
Z, Tyano S., Apter A, Weizman A Family based association study of
serotonin transporter promoter in suicidal adolescents: No association with
suicidality but a possible role in with violence traits Am J Med Genetics 105
(3):239-45 2001
100.
Zalsman G, Horesh N, Arzi R, Edelist D, Even DH, Tyano S, Poustka F, Apter
A Psychosocial diagnosis in psychiatrically hospitalized adolescents Compr.
Psychiatry 42(3):223-7 2001
101.
Apter A, Horesh N, Gothelf D, Graffi H, Lefkifker E Relationship
between self disclosure and serious suicidal behavior Compr Psychiatry 42
(1) :70-75 2001
102
Zalsman G, Frisch A, King RA, Pauls DL, Grice DE, Gelernter J, Alsobrook J,
Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman JF Case control and
family-based studies of tryptophan hydroxylase gene A218Cpolymorphism and
suicidality in adolescents. Am J Med Genet
Jul 8; 105(5): 451-7, 2001
103. Valevski A, Ratzoni G, Sever J, Apter A, Zalsman G, Shiloh R,
Weizman A, Tyano S. Stability of diagnosis: a retrospective cohort study of
Israeli psychiatric adolescent patients. J Adolesc. 24 (5) 625-633 (2001)
104. Koronya-Hamoui M, Danziger Y., Frisch A., Stein D., Leor S., Laufer N.,
Carel C., Fennig S., Mimouni M., Apter A Goldman B., Barkai G., Weizman A and Gak E(2002) Association
between anorexia nervosa and the hsKCa3 gene: a family based and case control
study. Molecular Psychiatry 7,82-85
105 Stein D., Asherov L.,Lublinsky E.,Sobol-Havia, D., Weizman A., and Apter
A., Socio-demographic factors associated with attempted suicide in two
Israeli cities between 1990 and 1998. J. Nev.Ment Dis. 190
(2) :115-8. 2002
106. Ratzoni G.,Gothelf D., Brand-Gothelf A., Reidman J., Kikenzon K., Gal
G., Phillip M., Apter A and Weizman R. Weight Gain associated with
Olanzepine and Risperidone in Adolescent patients: A comparative prospective
study. J Am Acad. Child and Adolesc.Psychiatry 41 (3):337-43, 2002.
107. Doron Gothelf, Bareket Falk, Pierre Singer, Michal Kairi, Moshe Phillip,
Levana Zigel, Irit Poraz, Siegal Frishman, Naama Constantini,
Gil Zalsman, Abraham Weizman,
and Alan Apter Weight Gain Associated With Increased Food
Intake and Low Habitual Activity Levels in Male Adolescent Schizophrenic
Inpatients Treated With Olanzapine Am J Psychiatry 159:1055-1057, 2002
A
Follow-up Study of Adolescent Attempted Suicide in Israel.
J Am Acad Child Adolesc Psychiatry. 2002 Nov;41(11):1342-1349
109.
Stein D, Orbach I., Shanit-Sela M., Har-Even D., Yaruslavski A., Rot D., Meged S
and Apter A. Suicidal tendencies and body image and experience in
Anorexia Nervosa and suicidal female adolescent inpatients (Psychother
Psychosom. 2003 Jan-Feb; 72(1): 16-25.)
110 A Apter., N Horesh., D Gothelf .,G Zalsman .,
Z Erlich ., N Soreni A Weizman Depression and Suicidal Behavior in
Adolescent Inpatients With Obsessive Compulsive Disorder (J Affect Disord. 2003
Jul;75(2):181-9.)
B 1. ORIGINAL ARTICLES IN
PRESS
1.
2. D.Gothelf,
A. Apter, J. Reidman, A. Brand-Gothelf, Y. Bloch, G. Gal, L. Kikinzon, S.
Tyano, R. Weizman, and G. Ratzoni. Olanzapine, risperidone and
haloperidol in the treatment of adolescent patients with schizophrenia (Journal
of Neurotransmission)
3.
N Horesh, Y Sever and A. Apter Life
Events and suicidal behavior in adolescence (Comprehensive Psychiatry)
4 D
Gothelf, R Gruber, G Presburger, I Dotan, A Brand-Gothelf, M.D., M
Burg, D Inbar, T Steinberg, A Frisch, A Apter, A Weizman M.D. Methylphenidate
Treatment for Attention- Deficit/Hyperactivity Disorder in Children and
Adolescents with Velocardiofacial Syndrome: An Open-Label Study ( J of
Clinical Psychiatry).
Articles Submitted For Publication
A.
Apter, A. H. Zohar, G. Ratzoni, M. Binder,
S. Kron, A. Dycian,
R. A. King, D.L. A. Weizman, D. Pauls D.J. Cohen. Performance of a
screening instrument for the detection of OCD in adolescence Acta
Scandinavica Psychiatrica
Zohar
A.H., Kaplan, D., Pauls, D. Weizman, A., Kron S., Dycian, A., King, R., Cohen,
D. Apter A. The natural course of Obsessive Compulsive Disorder in late
adolescence: A 12-18 month prospective follow up of epidemiologically
ascertained untreated adolescents J. Am. Acad. of Child and
Adolesc.Psychiatry
LIST
OF PUBLICATIONS_(Cont.)
B2. CASE REPORTS
1.
M. Roitman, A. Apter, S. Lahav and S. Tyano Amantadine treatment of the
malignant neuroleptic syndrome.
Harefuah, J. Israel Med. Assoc., 7: 333, 1981.
2.
J. Kronenberg, S. Tyano, A. Apter and H. Wijsenbeek
Treatment of transsexualism in adolescence. J. Adolescence,
4:177‑185, 1981.
3.
Y. Kaminer, A. Apter, S. Tyano, E. Livni and H. Wijsenbeek
Management of delayed hypersensitivity to haloperidol syrup.
Am. J. Psychiatry, 139(11): 1503‑1504, 1982.
4.
Y. Kaminer, A. Apter, S. Tyano, E. Livni and H. Wijsenbeek
Hypersensitivity to methylparaben. Am. J. Hospital Pharmacy, 1:
469‑470, 1982.
5.
A. Apter, Y. Kaminer, S. Tyano, N. Skurnik and R. Weitz:
Irritation temporate et pathologie arachnoide:
Reaction pseudo‑psychotique chez des adolescents et evouloution
sout traitment. Les Annales Medico‑Phychologiques, 7:
766‑778, 1982.
6.
A. Bleich, E. Bernout, A. Apter and S. Tyano Gilles de la Tourette
syndrome and mania in an adolescent. Br. J. Psychiatry, 146:
664‑665, 1985.
7.
S. Eldar, A. Bleich, A. Apter and S. Tyano
Elective mutism ‑ An atypical antecedent of schizophrenia. J.
Adolescence, 8:289‑292, 1985.
8.
M. Shein, A. Apter, Z. Dickerman, S. Tyano and N. Gadot
Encephalopathy in compensated Hashimoto thryroiditis: A clinical
expression of autoimmune cerebral vasculitis. Brain Dev. 8: 60‑64,
1986.
9.
A. Apter, A. Didi and S.
Tyano Treatment of secondary transsexualism on an adolescent unit. Harefuah
‑ J. Israel Med. Assoc. 118
(5) 250-2, 1990.
10.
M. Keren, A. Apter, A. Mani and S. Tyano Neuropsychiatric SLE in an adolescent inpatient. Harefuah
‑ J. Israel Med. Assoc. 120,
446-449 1991.
11.
I Iancu, Berezin M, G. Ratzoni, A. Apter and S. Tyano. Anorexia Nervosa
in a young diabetic. Harefuah-J. Israel Med. Assoc 122(6): 367-9. 1993
12.
I. Iancu, L. Kikenzon, G. Ratzoni, and A. Apter. Anorexia Nervosa
and Obssessive Compulsive Disorder in a young Russian immigrant. Harefuah-J.
Israel Med. Assoc 124 (8) 477-479. 1993
13.
A.Apter, G. Ratzoni, I Iancu, A. Weizman and S. Tyano. Ganser Syndrome in
two adolescent brothers. Journal of the American Academy of Child Psychiatry.
32:(3) 582-584 1993
14.
S. Hirschman, A. Apter, A. Weizman, M.Radvan. Anorexia Nervosa beginning
after the menopause Harefuah-J. Israel Med. Assoc. vol 131 (1-2) 10-12
1996
15..
Kohn Y, Fahum T, Ratzoni G. Apter A. Case Study: Aggression and sexual
offense in Asperger's syndrome . Israel Journal of Psychiatry 35, 4,
2593-299, 1998
B3. REVIEW ARTICLES
1.
A. Apter and S. Tyano Side effects of lithium treatment. Harefuah, J.
Israel Med. Assoc., 6: 303‑306, 1981.
2.
A. Apter, A. Weizman, R. Weizman, S. Tyano and H. Bellmaker
MBD ‑ A critical review.Harefuah ‑ J. Israel Med. Assoc.,
C:1‑12, 1981.
3.
J. Apter, A. Apter and S. Tyano Side effects and toxicity of lithium.
J. Family Pract. (USA),
15(6): 1101‑1106, 1982.
4.
E. Bernhout, A. Bleich and A. Apter Gilles de la Tourette
syndrome. Harefuah ‑ J. Israel Med. Assoc.,
CVVI(7): 314‑316, 1984.
5.
A. Bleich, A. Apter and S. Tyano Difficulties in the psychiatric
diagnosis of adolescents. Harefuah ‑ J. Israel Med. Assoc., CX(4):
187‑189, 1986.
6.
R. Blumensohn and A. Apter Depression
in childhood Harefuah ‑ J. Israel Med. Assoc.,
CX(3): 19‑21, 1987.
7.
A. Apter and S.Tyano. Childhood depression-a review
Isr. J. Psychiatry Relat Sci Vol 21,2,117-126. 1987
8.
Y. Cohen, Y. Kaminer and A. Apter
Suicide in children. Harefuah ‑ J. Israel Med. Assoc., CXV:
229‑232, 1987.
9.
I. Iancu and A. Apter (1991).
History of anorexia nervosa Ha refua Journal of the Israel Medical
Association 121: 405-407 1991
10.
I. Iancu and A. Apter. (1992) Anorexia Nervosa -The need for an
epidemiological screening instrument. Harefuah-J of the Israel Medical
Association 122: 5, 315-317.
11.
Iancu, G. Ratzoni, A. Weizman and A. Apter. (1993) Trichotillomania-the
hair-pulling insanity Harefuah-J
of the Israel Medical Association 124:6:350-353.
12.
A. Apter, A. Weizman and S Tyano Teenage
violence Israel Journal of Psychiatry and Related Sciences (editorial)
1994
13.
S. Hirschman, R. Weizman and A. Apter (1994) Adolescent suicide Harefuah-J
of the Israel Medical Association 26:661-663
14.
I.Iancu, G. Spivak B Ratzoni G, A. Apter and A. Weizman (1994) The
socio-cultural theory in the development of anorexia nervosa Psychopathology
27:29-36
15.
A. Apter, M.Keren and S. Tyano (1995) Revue des aspects biologiques de le
aggression ar de l'acte suicidal La
Semaine des Hopitaux 71:1-2; 33-39.
16.
S Gur, A. Apter and M Granek. ADD in adults Harefuah-J of the Israel
Medical Association 130 (12):851-4, 1996
17.
Apter A.and Weizman A. Methylphenidate:Between rhetoric and data
(editorial) Israel Journal of Psychiatry 34 (3) 173, 1997
18.
A. Apter. Child Psychiatry in Israel-towards the millenium (editorial) Israel
Journal of Psychiatry 35, 251-252 1998
19
Gothelf D, Brand-Gothelf A, Apter A, Phillip M, Weizman A, Feinaru
M Weight gain due to anti-psychotic medication Harefuah-J of the Israel
Medical Association 138 (7) 572-8 2000
20
Field J, Zalsman G and Apter A (2001)
Violence and homicide in psychotic
patients Harefuah-J of the Israel Medical Association 140 (30)
243-247
21.
Ben-Dor DH, Laufer N, Apter A, Frisch A, Weizman A. Heritability, genetics
and association findings in anorexia nervosa.Isr J Psychiatry Relat Sci.
2002;39(4):262-70.
22.
Zalsman G, Frisch A, Apter A, Weizman A. Genetics of suicidal behavior:
candidate association genetic approach.Isr J Psychiatry Relat Sci.
2002;39(4):252-61.
C. BOOKS
Alan
Apter and Noa Offer. (Hebrew)
Suicide in Adolescence Henrietta Zold Institute Jerusalem 1998
Apter
A, Hattab Y, Tyano S and Weizman A. Introduction to child psychiatry (Hebrew)
Dionon Tel Aviv 1998
Apter
A and Freudenstein O: Suicide in adolescence Dionon Tel Aviv 2001
King
R and Apter A. Adolescent Suicide (Cambridge
University Press
D. CHAPTERS IN BOOKS
1.
I. Orbach, A. Apter
and S. Tyano. Attitudes towards death in suicidal adolescents.
In: New directions in affective disorders. (Eds. B. Lerer and S. Gershon). Springer
Verlag, New York (1980).
2.
A. Apter, A. Ram and S.
Tyano.
Dexamethasone suppression test in hospitalized adolescents.
In New directions in affective disorders (Eds. B. Lerer and S. Gershon).
Springer Verlag, New York (1989).
3.
A. Apter, S. Brown, M. Korn and H.M. van Praag Serotonin in
childhood psychopathology. In: Serotonin in psychiatry (Eds. S. Brown and H.M. van Praag).
Bruner Mazel, New York (1990).
4.
A. Apter, S. Brown, M. Korn and H.M. van Praag
Serotonin and dysregulation of aggression.In:
Serotonin in psychiatry (Eds. S. Brown and H.M. van Praag).Bruner Mazel,
New York (1990).
5.
M. Korn, S. Brown, A. Apter and H.M. van Praag Serotonin and
suicide: A functional/dimensional viewpoint. In: Suicide (Ed. R. Lester).
Charles Press, Philadelphia. 1990
6.
A. Apter and R. Plutchik
Overview. In: Clinical and
research perspectives in suicide and violence
(Eds. R. Plutchik, H.M. van Praag and A. Apter). Bruner Mazel, New York,
1990.
7
S. Tyano and A. Apter Suicidality
and conduct disorder in adolescence. Proceeding of the 8th World Congress of
Psychiatry (1994).
8.
H. Conte and A. Apter Life
style index .In Ego Defenses: Measurement and Theory (ed R. Plutchik and H
Conte) John Wiley and Sons, New York, 1995.
9
A. Apter. Continuity and discontinuity in male adolescent suicide In F.
Laddamme, J Ottino and C. Pawlak (Ed) Adolescent Suicide.
Masson, Paris 1995 (French).
10.
RA King and A. Apter Child and adolescent suicide. In R. Michels (Ed)
Psychiatry Vol 2, Philadelphia Lippencott 1995
11.
A. Apter and S.Tyano. Adolescent suicide. In
E. Benedek (Ed) International Review, American Psychiatric Association Press
1995
12.
A. Apter Suicide in children and adolescents In Botsis AJ, Soldatos CR
and Stefanis CN (Eds) Suicide: Bio-psychosocial Approaches.Amsterdam (1997)
Elsevier
13.
A. Zohar, A Apter, Robert King, David Pauls, James Leckman and Donald
Cohen. Epidemiological Studies. In: Leckman JF and Cohen DJ Tourette’s
Syndrome (1999) John Wiley and
Sons. New York
14.
A Apter and O Freudenstein. Adolescent Suicide In: Hawton K and Van
Heeringen G International Handbook of Suicide (2000) John Wiley and Sons
Chichester
15.A
Apter. Adolescent Suicide In:(Wassermann D ed.) Suicide-an
unnecessary death. Martin Dunitz
(London) (2001).
16.
A. Apter. Holon/ Bat Yam. In: Brille Brahe (ed.) WHO/ Euro Mullticenter Study on
Parasuicide. Facts and Figures WHO Regional Office Copenhagen 2001
17
A Apter and H Ofek Personality constellations in adolescent suicide In
Understanding Suicide (Eds Van Heeringen C John Wiley and Sons) Chichester 2001
18
Gil Zalsman and Alan Apter Serotonergic Metabolism and Violence
/Aggression In: Glicksohn J [ed]. The Neurobiology of Criminal
Behaviour. Kluwer Academic Publishing 2001
19.
A. Apter: Personality and Adolescent Suicide In: (eds) Connolly J. Youth
Suicide Irish Association of Suicidology Ennis County Clare2001
20.A
Apter and G. Zalzman Suicidal behavior and depression in adolescence In:
Suicide Risk and Protective Factors in the New Millenium (O Grad ed.) Cakarjev
Dom Lublijana 2001
21.
Shemesh E, Gothelf D, Apter A, Newcorn J and Yehuda R.
Assessment and
Treatment
of Depression in Medically Ill Children. Expert Review of
Neurotherapeutics,
(in press).
22.
Apter A and Harubi L. Depression and suicidal behavior
In: Student Health (eds. B Kanushkoni, Y Amitai, M Horowitz
Ministry of Health Jerusalem 2003
G. BOOKS EDITED
1.
R. Plutchik, A. Apter and H.M. van Praag
Clinical research perspectives in suicide and violence.
Bruner Mazel, New York, 1990.
H. OTHER PUBLICATIONS
1.
I. Modai, A. Apter, M. Golomb and H. Wijsenbeek
Urinary MHPG and response to amitriptyline. Arch. Gen. Psychiatry
(Letter), 40(4): 467, 1983.
2.
A. Apter, I. Dagan, S. Tyano and R. Skurnik
Education sexuelle pour adolescents hospitalizes en hopital
psychiatrique.
Extraits de compte rendu congres de psychiatrie et de neurologie de
langue Francais. 1983.
3.
S.L. Brown, M. Korn and A. Apter Serotonin and aggression.
(Letter) Psychiatric Times, July 4, 1988.
4.
A. Apter Child
and adolescent psychiatry in Israel. International Child Mental Health. 1
(2), 28‑29, 1989.
5.
A. Apter. Legal aspects of child and adolescent psychiatry in Israel. Forensische
Psychiatrie und Mabbegelvolzug: Aspekte unt Entwicklungen in Israel und
Deutshland. Gestzteke. Ravensburg Weibenau Juli 1990
6.
A. Apter and G. Ratzoni Youth suicide. Le Da-at
21, 5, 9-11. 1991
7.
A. Apter. Eating disorders-the psychobiology of control. Separation and
Individuation in Adolescence. Summit Institute Jerusalem 1991.
8.
S. Tyano and A. Apter. Child and adolescent psychiatry-Israel
1991.
International Child Mental Health 1 (3), 15-16 1991.
9.
I.Iancu, G.Ratzoni and A. Apter Eating disorders in insulin dependent
diabetes mellitus BMJ 303: 714, 1991 (letter)
10..
A. Apter Adolescent psychiatry in Israel I. International Society
Adolescent Psychiatry 6(1) 3-4, 1992.
11.
I. Iancu, G. Ratzoni, A. Weizman and A. Apter ( 1992) More Fluoxetine
experience J. Am. Acad. Child Adolesc. Psychiatry
31: 4 755-756 (letter).
12.
A. Apter Adolescent suicide Maccabiton
October: 12-13, 1992
13.
A. Zohar, G. Ratzoni, M. Binder, Pauls D., A. Apter, S. Kron, A. Dycian,
R. King, J. Leckman, D. Cohen (1993). The role of childhood symptoms in adolescent onset
obsessive compulsive disorder and other anxiety disorders American Society of
Human Genetics 53 (3) sup # 882
14.
A. Zohar, G. Ratzoni, M. Binder, Pauls D., A. Apter, S. Kron, A. Dycian,
R. King, J. Leckman, D. Cohen. An
epidemiological study of obsessive compulsive disorder and anxiety disorders in
Israeli adolescents. Psychiatric Genetics 3 (3): 184. 1993
15.
A. Apter Adolescent
psychiatry in Israel II. International Society Adolescent Psychiatry 7(2)
4-5, 1993.
16.
Horesh N., Apter, A. et al. Acontecimentos vitales Y anorexia nervosia
grave en adolescentes Focus on Psychiatry, volumen3, numero 2 p.47 1995.
17.
Horesh N., Apter A et al. Life events and severe anorexia nervosa in adolescence Psychiatry
Digest Feb. 1 1996 pp 23.
18.
International Conference on Youth Suicide. IACAPAP News Letter No IV Summer
1996.
1. Makhoul C, Trifonov EN. Periodical recurrence of
translation pause sites
in mRNA and standard sizes of protein sequence
segments and independently
folding domains (abstract). J. Biomolec. Str. Dyn.
14, 787-788 (1997).
2. Trifonov EN, Denisov DA, Makhoul C. Interacting
sequence patterns. Math.
Modelling and Sc. Comp.9,24-29 (1998).
3. Makhoul C, Trifonov EN. Distribution of rare
triplets along mRNA of
prokaryotes and their relation to protein folding
J. Biomolec. Str. Dyn.
20: 413-420 (2002).
1) 10th Conversations on Biomolecular Structure and
Stereodynamics. Albany,
NY, June 1997.
Title: Makhoul C, Trifonov EN. Periodical recurrence
of translation pause
sites in mRNA and standard sizes of protein sequence
segments and
independently folding domains.
2) 1st International Conference on Complex Systems.
NH, USA. September 1997
On: The complexity of periodical recurrence of
translation pause sites in mRNA
3) 1st International Peptide Symposium. Kyoto, Japan,
November 1997.
On: Periodical recurrence of translation pause sites
in prokaryotic mRNA and protein independently folding domains.
4) 1st Peptide Engineering Meeting. Osaka, Japan,
December 1997.
On: Periodicity of translation pausing sites and
independently folding protein domains.
5) The EMBO Workshop: Protein Folding and Misfolding
Inside and Outside the Cell. Oxford, UK, March 1998.
Title: Makhoul C, Trifonov EN. Clusters of rare
triplets in mRNA and their relation to protein folding.
| Network
of Excellence |
CARiMan |
The
Internet Portal for Computer Aided Risk Management |